nnnnnnnnnnnnBIOMAT Group Sep 2008nnnnnnnnnnnnnnnnnnnnnnn BIOMAT Group Sep 2007

Teaching is carried out through various courses and the Biotechnology Research Unit (BRU) (Department of Biological Sciences, METU) contributes substantially to this by courses directly relevant with the Biomaterials field. These are Biomedical Materials and Instrumentation (Bio 414), Biomaterials (Bio 514), Macromolecules in Biomedicine and Biotechnology (Bio 554), and Controlled Release Systems and Drug targeting (Bio 580), Advanced Biomaterials (Bio 584),Research conducted are concentrated on biodegradable hard tissue implants, tissue enginering (bone, cartilage, retinal pigment epithelium, nesrve, cardiac tissue, and cornea), controlled release systems, immobilization for the construction of biosensors and bioreactors, and liposomes (photodynamic, for gene transfer and drug delivery).The Biomedical Science and Technology Symposia (BIOMED's) initiated by us along with some colleagues have reached their 15^th year in 2009 and are all at international level.

*** 15^th Biomedical Science and Technology Symposium (BIOMED 2009) took place at METU Northern Cyprus Campus from August 16 to August 19. http://www.ncc.metu.edu.tr/etc2/biomed_sempozyum.php

Recent Publications:

2009

• P. M. Davidson, H.Ozcelik, V. Hasirci, G.Reiter, .K.Anselme, Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus, 21, 3586–3590, 2009.
• N.Ozturk; A.Girotti; G.T.Kose; J.C. Rodriguez-Cabello,V. Hasirci, DYNAMIC CELL CULTURING AND ITS APPLICATION TO MICROPATTERNED, ELASTIN LIKE PROTEIN-MODIFIED POLY(N-ISOPROPYLACRYLAMIDE)SCAFFOLDS (in press, BIOMATERIALS)
• P.Yilgor, K.Tuzlakoglu, R.L.Reis, N.Hasirci, V.Hasirci, Incorporation of a Sequential BMP-2/BMP-7 Delivery System into Chitosan-Based Scaffolds for Bone Tissue Engineering, Biomaterials, doi:10.1016/j.biomaterials.2009.03.024, 2009
• P.Yilgor, N.Hasirci, V.Hasirci, Sequential BMP-2/BMP-7 Delivery From Polyester Nanocapsules, Journal of Biomedical Materials Research Part A, in press.
• P. Zorlutuna, Z. Rong, P. Vadgama and V. Hasirci, Influence of Nanopatterns on Endothelial Cell Adhesion: Enhanced Cell Retention under Shear Stress, Acta Biomaterialia, in press.
• P.Zorlutuna, P.Yılgör, F.B.Başmanav, V.Hasırcı, Biomaterials and tissue engineering research in Turkey: The METU Biomat Center experience, Biotechnology Journal, DOI 10.1002/biot.200800335, 2009.
• P. Zorlutuna, A. Elsheikh and V. Hasirci, Nanopatterning of Collagen Scaffolds Improve the Mechanical Properties of Tissue Engineered Vascular Grafts, Biomacromolecules , 10 (4), 814-821, 2009.
• Yamak, O., Kalkan, N.A., Aksoy, S., Altinok, H., Hasirci, N. Semi-interpenetrating polymer networks (semi-IPNs) for entrapment of laccase and their use in Acid Orange 52 decolorization, Process Biochemistry, Article in Press, 2009.

2008

• N. E. Vrana, NBuilles, V. Justin, J. Bednarz, G. Pellegrini, B. Ferrari, O Damour, D. J. S. Hulmes, and V. Hasirci. Development of a Reconstructed Cornea from, Collagen-Chondroitin Sulfate Foams and Human Cell Cultures. Investigative Ophthalmology & Visual Science 49 (12), 5325-5331, 2008.
• P.Yilgor, D.Yucel, H.Kenar, V.Hasirci. Polyhydroxyalkanoates: A Versatile Class Of Biopolymers, And Their Biomedical Potential, In Brazilian Network On Green Chemistry: Awareness, Responsibility And Action , Ed. J.O.B.Carioca, Chapter 20, 415-431, 2008.
• E.A. Aksoy, A.Motta, M.Fedel, C.Migliaresi , V.Hasirci, N.Hasirci, Plasma Protein Adsorption and Platelet Adhesion on Heparin-Immobilized Polyurethane Films, J.Bioactive and Compatible Polymers, 23 (6), 505-519, 2008.
• E. Vrana, N. Builles, O. Damour, A. Aydinli, V. Hasirci, Contact Guidance Enhances the Quality of a Tissue Engineered Corneal Stroma, J. Biomedical Materials Research Pt A. 84A (2) 454-463, 2008.
• A.Ndreu, L.Nikkola, H.Ylikauppila, N.Ashammakhi, V.Hasirci, Electrospun Biodegradable Nanofibrous Mats for Tissue Engineering, Nanomedicine, 3(1) 45-60. 2008.
• H. Kenar, A. Kocabas, A. Aydinli, V. Hasirci, Chemical and Topographical Modification of PHBV Surface to PromoteOsteoblast Alignment and Confinement (J. Biomedical Materials Research Pt A, Volume 85A (4), 1001-1010, 2008[PDF]
• N.E. Vrana, N. Builles, V. Justin, J. Bednarz, G. Pellegrini, B. Ferrari,. Damour, D.J.S. Hulmes, V. Hasirci, Development of A Reconstructed Cornea From Collagen-Chondroitin Sulfate Foams And Human Cell Cultures, IOVS, 49, 5325-5331, 2008[PDF]
• F. B. Basmanav, G. Torun Kose, V. Hasirci, Sequential Growth Factor Delivery From Complexed Microspheres For Bone Tissue Engineering, Biomaterials, 29 (31),  4195-4204, 2008.
• P. Zorlutuna, N. Hasirci, V. Hasirci, Nanopatterned Collagen Tubes for Vascular Tissue Engineering, Tissue Engineering and regenerative medicine (Short Communication) 2 (6),  373 - 377, 2008.
• K. Kamışoğlu, E. A. Aksoy, B. Akata, N. Hasirci and  N. Baç, Preparation and Characterization of Antibacterial Zeolite - Polyurethane Composites, J. Applied Polymer Science, 110, 2854-2861, 2008.
• Melike Oruç, M. Gürhan Ulusoy, Yüksel Kankaya, Uğur Koçer, Kemal Şerbetçi, Nesrin Hasirci, Pulley reconstruction with different materials: Experimental study, Annals of Plastic Surgery, 61, 2, 215-220, 2008.
• Ayse E Aksoy, Vasif Hasirci, Nesrin Hasirci, Surface Modification of Polyurethanes with Covalent Immobilization of Heparin, Macromolecular Symposia, Macromol. Symp. 269, 145-153, 2008.
• Canturk Ozcan, Pınar Zorlutuna, Vasıf Hasirci, Nesrin Hasirci, Influence of Oxygen Plasma Modification on Surface Free Energy of PMMA Films and Cell Attachment, Macromolecular Symposia, Macromol. Symp. 269, 128-137, 2008.
• S. Uguralp, M. Akin, A B. Karabulut, B. Harma  A. Kiziltay, TR. Kıran, N. Hasirci, Reduction of peritoneal adhesions by sustained and local administration of epidermal growth factor,  Pediatr Surg Int., 24, 2, 191-197, 2008.
• Pinar Yilgor, Rui A. Sousa, Rui L. Reis, Nesrin Hasirci, Vasif Hasirci, 3D Plotted PCL Scaffolds for Stem Cell Based Bone Tissue Engineering, Macromolecular Symposia, Macromol. Symp. 269, 92-99, 2008.
• Haydar Altinok, Serpil Aksoy, Hayrettin Tümtürk, Nesrin Hasirci, Covalent Immobilization of Invertase on Chemically Activated Poly(Styrene-2-hydroxyethyl methacrylate) Microbeads, Journal of Food Biochemistry, 32, 299-315, 2008.
• Hayrettin Tümtürk, Gökhan Demirel, Haydar Altinok, Serpil Aksoy, Nesrin Hasirci, Immobilization of  Glucose Isomerase in Surface Modified Alginate Gel Beads, J. Food Biochemistry, 32, 234-246, 2008.
• S. Uguralp, M. Akin, A B. Karabulut, B. Harma  A. Kiziltay, TR. Kıran, N. Hasirci, Reduction of peritoneal adhesions by sustained and local administration of epidermal growth factor,  Pediatr Surg Int., 24, 2, 191-197, 2008.
• C. Ozcan; N. Hasirci, Evaluation of Surface Free Energy for PMMA Films, Journal of Applied Polymer Science, 108, 438-446, 2008.
• M. Fedakar Senyucel, M. Bingol-Kologlu, R. Vargun, C. Akbay, F.Nurşen Saraç, N. Renda, N. Hasırcı, G. Gollu, H. Dindar, The effects of local and sustained release of Fibroblast growth factor on wound healing in esophageal anastomoses, J. Pediatric Surgery, 43, 2, 290-295, 2008.

2007

• N.E.Vrana, A.Elsheikh, N.Builles, O.Damour, V.Hasırcı, Effect of Human Corneal Keratocytes and Retinal Pigment Epithelial Cells on the Mechanical Properties of Micropatterned Collagen Films Biomaterials, 28, 4303-4310, 2007.
• P. Zorlutuna, N. Builles, O. Damour, A. Elsheikh, V. Hasirci, Influence of Keratocytes and Retinal Pigment Epithelial Cells on the Mechanical Properties of Polyester-Based Tissue Engineering Micropatterned Films, Biomaterials, 28, 3489-3496, 2007.
• N. Ashammakhi, A. Ndreu, Y. Yang, H. Ylikauppila, L, Nikkola, V. Hasirci, Tissue Engineering: A New Take-off Using Nanofiber-based Scaffolds, The J. Craniofacial Surgery, 18(1), 3-17, 2007.
• V.Hasirci, D.Yucel, 'Polymers Used in Tissue Engineering, in 'Encyclopedia of Biomaterials and Biomedical Engineering, 1:1,1-17,2007, http://www.informaworld.com/smpp/title~content=t713172959
• D.Yucel, N.Ozer, V.Hasirci, Construction of a choline biosensor through enzyme immobilization on a poly(2-hydroxyethylmethacrylate) grafted Teflon film, J. Applied Polymer Science 1004, 3469-3477, 2007.
• N. E Vrana; N. Builles; H. Koçak; P. Gülay; V. Justin; M Malbouyres; F Ruggiero; O Damour; V. Hasirci, EDC/NHS Crosslinked Collagen Foams As Scaffolds For Artificial Corneal Stroma, J. Biomater. Sci. Polymer Edn, 18(12) 1527-1545, 2007.
• N.Hasirci, Micro and Nano systems in Biomedicine and Drug delivery, in 'Nanomaterials and Nanosystems for Biomedical Applications', Editor: M. Reza Mozafari, pp:1-26, Dordrecht, Netherlands, Springer, 2007
• Karakayali, F., Haberal, N., Tufan, H., Hasirci, N., BaSaran, O., Sevmis, S., Akdur, A., Kiziltay, A., Haberal, M., Evaluation of neointimal hyperplasia on tranilast-coated synthetic vascular grafts: An experimental study, Journal of Investigative Surgery 20 (3), pp. 167-173, 2007.
• C. Ozcan, N.Hasirci, Plasma modification of PMMA films, surface free energy and cell-attachment studies, J. Biomater Sci. Polymer Edn., 18, 6, 759-773, 2007.
• Nesrin Hasirci, E. A. Aksoy, Synthesis and Modification of  Polyurethanes for medical Applications, High Performance Polymers, 19, 621-637, 2007.
• Kemal Serbetci, Hakan Kulacoglu, Ali Onder Devay, Nesrin Hasirci, Effects of Resterilization on Mechanical Properties of Polypropylene Meshes, The American Journal of Surgery, AJS 19, 3,  376-381, 2007.
• E.Ayse Aksoy, Burcu Akata, N. Bac, N.Hasirci, Preparation and characterization of zeolite Beta-polyurethane composite membranes, Journal of Applied Polymer Science, 104, 3378-3387, 2007.