BIOMED2
The Second National Biomedical Science and Technology Symposium (BiOMED 2) that took place on 21-23 September 1995 at the Middle East
Technical University (Ankara, Turkey) was organized with the intention of gathering scientists , bureaucrats , medical device producers and suppliers
working in this rapidly developing interdisciplinary field and to encourage young researchers to find a place for themselves in the wide spectrum of
very interesting subjects. As a result of this interdisciplinary approach in the calls for papers, contributors from various fields came to the Symposium
and brought their experiences and findings from their respective fields and enriched it immensely.
When the Program is examined it will be noticed that most of the researchers who attended the meeting were from a few centers in the
country. Our wish is that the number of these centers or nuclei increases, and they become stronger in terms of their manpower and
facilities, and eventually make the University-Industry Collaboration dream of scientific and technological development in the Biomedical field can be
achieved. I would like to express my gratitude to all who contributed to this Symposium by attending, by supporting and by enabling us to use their
facilities these, special thanks are due to the METU Administration, Symposium Scientific Committee , Local Organizing Committee and to our
Sponsors.
Vasif Hasirci
Professor
Symposium Chairman
Committees Involved in the Organization of
BiOMED 2
Scientific Committee
U.Akbulut (METU) N.Akkas (METU)
G.Alaeddinoglu (METU) Y.Arica (Krkkale University)
S.Kas (Hacettepe University) N.Hasirci (METU)
V.Hasirci (METU) E.Piskin (Hacettepe University)
Y.P.Tan (Bosphorus University) A.Tumer (Hacettepe University)
Local Organizing Committee
Y.Arica (Kirikkale University) A.Borucu (METU)
I.Gursel (METU) V.Hasirci (METU)
C.Halicigil (METU) F.Kok (METU)
M.R.Mozafari (METU) G.Torun (METU)
The Sponsors
Middle East Technical University
Scientific and Technical Research Council of Turkey
Sagerstip
Incekara A.S
Doga Ltd.
FAKO
PANEL DISCUSSION
on
THE STATE OF THE ART IN BIOMEDICAL SCIENCE AND TECHNOLOGY IN TURKEY
PANELISTS
Mr. Ertugrul Alpkaya (Regulations and Rules; Ministry of Health)
Mr. Alptekin Aydin (Viewpoint of the Manufacturer)
Prof. Ziya Ider (Educational Aspects)
Prof. Filiz Oner (Research Aspects; Pharmaceuticals and Biotechnology)
Prof. Vasif Hasirci (Research Aspects; Biomaterials and Biotechnology)
CONTENTS
RESPONSIVE POLYMERIC DRUG DELIVERY SYSTEMS 1
H.S.Kas
BINARY DIFFUSION FROM GELATIN/GUM ARABIC MICROCAPSULES 3
B.Övez, S.Peker
TESTOSTERONE CONTAINING POLYHYDROXYALKANOATE MICROCAPSULES AND SOLVENT CAST
FILMS:EFFECT OF TEMPERATURE AND 60Co-g IRRADIATION ON RELEASE RATE 5
I Gursel ,V. Hasirci
PRODUCTON OF CHLORAMPHENICOL LOADED POLY(D,L -LACTIDE) SPONGES 7
A.Kozluca, E. B.Denkbas, E.Piskin
BIOMATERIALS WITH LIMITED SERVICE LIVES: DEGRADABLE SYSTEMS AND LIPOSOMES 9
V. Hasirci
RECENT ADVANCES IN THE CHEMICAL SYNTHESIS OF BIOCERAMIC POWDERS IN METU 11
A.C.Tas, M.Timucin
LIPOSOMAL VACCINES:EFFECT OF LOCALIZATION OF ANTIGEN AND CYTOKINE ON IMMUNIZATION 13
M.Gursel,G.Gregoriadis
MUCOSAL ADHESIVE PREPARATIONS 15
Y. Çapan
THE INTERACTION BETWEEN NICARDIPINE HYDROCHLORIDE AND POLYMERIC MICROSPHERES FOR
A CONTROLLED RELEASE SYSTEM 17
N.Yuksel,T.Tinçer,T.Baykara
CHITOSAN - POLYMERIC PROPERTIES AND APPLICATIONS 19
H.S.Kas
CONTROLLED DRUG DELIVERY FROM HYDROGEL MATRICES 21
F.N.Kok , M.Y.Arica , V.Hasirci
EFFECTS OF BIOCORAL AND CALCIUM CARBONATE IMPLANTATION ON BONE HEALING 23
A.Gurmeric, P.Korkusuz, M.Kokden, N.Çakar, K.Araz
DETECTION OF NEURAL ACTIVITY IN BRAIN SLICES USING OPTIC METHODS 25
Y.P.Tan
A NEW WOUND DRESSING MATERIAL: POROUS POLYURETHANE MEMBRANES 26
Ç.Yavuz, A.. Serbetci, O. Abbasoglu, A. Sungur, M. Tuncel, H.Cicek, A. Tuncel, . Sayek, E. Piskin
ADVANCES IN PC-BASED INSTRUMENTATION OF BIOELECTRIC SIGNALS 27
Y.Z.der, H.A.Gucer
ASSESSMENT OF FRACTURE HEALING BY USE OF VIBRATION METHODS 29
O.Akkus,F.Korkusuz,N.Akkas
OBSERVATION OF BIOMOLECULES BY SCANNING TUNNELING MICROSCOPY 31
M.H.Zareie,E.Piskin
RELATIONSHIP BETWEEN IMMOBILIZED ENZYME ACTIVITY AND CARRIER COMPOSITION 33
E.Emregul,S.Sungur,U.Akbulut
PHOTORESPONSE OF BACTERIORHODOPSIN IMMOBILIZED ON CELLULOSE ACETATE MEMBRANE 35
V.Sediroglu, L.Turker, M.Yucel, U.Gunduz, I. Eroglu
IMMOBILIZATION OF AMYLOGLUCOSIDASE ONTO ACTIVATED pHEMA/EGDMA MICROSPHERES 37
M.Y.Arica, N. G. Alaeddinoglu,V. Hasirci
CONGO RED AND Zn(II) DERIVATIZED POLY(EGDMA-HEMA) SORBENTS FOR SPECIFIC ALBUMIN ADSORPTION 39
A.Denizli, B.Salih,A.Kozluca, K.Kesenci, E.Piskin
IDENTIFICATION OF ACTIVE LEUKOCYTES BY POLYMERIC MICROSPHERES DURING CARDIOPULMONARY BY-PASS41
H.Ayhan,A.Y.Rad,N.Bingol,E.Piskin
ELECTROCHEMICAL POLY(p-AMINOPHENOL) SYNTHESIS AS A BIOSENSOR MEMBRANE 43
E.Ekinci,A.E.Karagozler
A NEEDLE TYPE GLUCOSE BIOSENSOR CONSTRUCTED BY ENTRAPMENT OF GLUCOSE OXIDASE WITH THE
HELP OF O-PHENYLENEDIAMINE 45
M. Ozsoz, T.Dalbast, E.Klnç,L.Gokgunneç
DESIGN AND CONSTRUCTION OF A TRANSCUTANEOUS ELECTRODE FOR THE MEASUREMENT OF
BLOOD OXYGEN LEVEL 47
C. Kocum, S. Mutlu, E. Piskin
CONSTRUCTION OF A GLUCOSE SENSOR BASED ON pHEMA MEMBRANES 49
M. Y. Arica, E. Karpuzoglu. V. Hasirci
POLYELECTROLYTE COMPLEXES IN IMMUNOLOGY 51
M.I.Mustafaev
SURFACE MODIFICATION OF POLYURETHANE AND PVC BY BLENDING WITH SILOXANE CONTAINING
COPOLYMERS AND ITS EFFECT ON THE BIOCOMPATIBILITY OF THE RESULTANT SYSTEMS 53
.Ylgör, E.Ylgor
HORMONE-DEPENDENT BIOLUMINESCENT CELL MODELS 55
E. Demirpence, D. Gagne, J.-C. Nicolas, M. Pons
CALCIUM HYDROXYAPATITE CERAMICS IN ORTHOPAEDIC SURGERY 57
F. Korkusuz
USE OF BIORESORBABLE INTERFERENCE SCREWS IN FRONT ANTERIOR CRUCIATE LIGAMENT SURGERY 59
M.N.Doral,G.Leblebicioglu
BIOLOGICAL REPAIR OF THE CARTILAGE USING CARBON FIBER IMPLANTS 60
O._.Atik
EVALUATION OF HYDROXYAPATITE IMPLANTATION ON BONE HEALING 61
A.Gurmeric, P.Korkusuz, M.Kokden, N.Çakar, K.Araz
BIODEGRADABLE IMPLANTS FOR THE FIXATION OF FRACTURES 63
H. Yetkin , A.M.Vural , S.Sarban
USE OF HYDROGELS AS BIOMATERIALS 65
N.Hasirci
COVALENT COUPLING OF POLYHYDROXYALKANOATES AND POLYSACCHARIDES AND THEIR POTENTIAL
APPLICATION AS A BIOMATERIAL 67
I. Gursel ,V. Hasirci
SYNTHESIS OF POROUS, MONODISPERSE POLYSTYRENE MICROSPHERES FOR BIOMEDICAL APPLICATIONS 69
A. Tuncel, H.Cicek, C. Alagoz, M. Tuncel
HEMA-COLLAGEN COPOLYMER SYNTHESIS INITIATED WITH CERIC AMMONIUM
NITRATE-GLUTARALDEHYDE REDOX SYSTEM 70
H. Cicek, A. Denizli, A. Tuncel
INVESTIGATION OF THE DRUG RELEASE FROM OPHTHALMIC GEL PREPARATIONS 71
A.Bozkir , A.Aydnl
EFFECT OF FORMULATION FACTORS ON PROPERTIES OF CONTROLLED - RELEASE PLGA
MICROSPHERES CONTAINING PROTEIN 73
J.Akbuga, M.Uysal, F.Arcoglu
CHITOSAN FILMS AS VEHICLES FOR TRANSDERMAL DRUG DELIVERY 75
Y. Bolgul, S. Hekimoglu, S. Kas, A. A. Hincal
IMMUNOGLOBULIN G DESORPTION AND REUSEABILITY OF PROTEIN A AND DNA IMMOBILIZED PHEMA SORBENTS 77
A.Denizli, F.K.Denizli, E.Piskin
SYNTHESIS OF PMMA MICROBEADS AND GLUCOSE OXIDASE IMMOBILIZATION 79
V.Bulmu_, H.Ayhan , E.Piskin
IMMOBILIZATION OF GLUCOSE OXIDASE AND UREASE WITH TWO DIFFERENT METHODS 81
.Gursel,M.Y.Arca,V. Hasirci
ADSORPTION OF BOVINE SERUM ALBUMIN ONTO N-VINYL-2-PYRROLIDONE-ALLYLTHIOUREA
COPOLYMER HYDROGELS 83
N.Pekel, M.Sen, O.Guven
IMMOBILIZATION OF ß-GALACTOSIDASE ON pHEMA MICROSPHERES AND MEMBRANES 85
E. T. Baran, O. Adali, M. Y. Arica, V. Hasirci
IMMOBILIZATION OF AMYLASE ON POLYMERIC MICROSPHERES 87
H.Tumturk, S.Aksoy,N. Hasirci
IMMOBILIZATION AND ACTIVITY STUDIES OF UREASE ENZYME 89
H.Demircioglu, A.Tanyolac, N.Hasirci
SYNTHESIS OF STIMULI -RESPONSIVE COPOLYMERS SENSITIVE TO TEMPERATURE AND pH 91
H. Cicek, A. Tuncel
SYNTHESIS OF STIMULI-RESPONSIVE POLYMERS WITH A NOVEL REDOX INITIATOR SYSTEM 92
H. Cicek, A. Tuncel
PREPARATION OF POLYURETHANE ELASTOMER FOR BIOMEDICAL APPLICATIONS 93
K.Ulubayram, N.Hasirci
DEXAMETHASONE SODIUM PHOSPHATE LOADED ERYTHROCYTES: IN VITRO-IN VIVO EVALUATION 95
.Yilmaz, F.Uner, E.Yesilada, A. A.Hincal
INFLUENCE OF SOME ALIPHATIC AMINO ACIDS ON THE SWELLING BEHAVIOR OF ACRYLAMIDE HYDROGELS 97
E. Karadag, D. Saraydn, H. N. Uztop, O. Guven
VOLTAMMETRIC ANALYSIS OF SOME CATECHOLAMINES WITH CONDUCTING POLYMER ELECTRODES 99
G.Erdogdu,A.E.Karagozler
CHANGING THE LIPOSOMAL SURFACE PROPERTIES USING LOW MOLECULAR WEIGHT HEPARIN 101
G.Torun , M.Y.Arica , V.Hasirci
LIPOSOME-DERIVED GENE DELIVERY 103
M.R.Mozafari , M.Y.Ozden , R.I.Zhdanov , V.Hasirci
INFLUENCE OF COMPOSITION ON STRUCTURAL STABILITY OF LIPOSOMES 105
A. Tezcaner, M.Y. Ozden, V. Hasirci
SYNTHESIS OF PLA AND PGLA'S WITH DIFFERENT MOLECULAR WEIGHTS AND THEIR USE IN 107
ANTIBIOTIC RELEASE
Y.Ozalp , N.Ozdemir , V.Hasirci
APPLICATION OF FIELD FLOW FRACTIONATION TECHNIQUE ON THE ALBUMIN MICROSPHERES 109
H.Cicek, A.Tuncel
PANEL DISCUSSIONS:
THE STATE OF THE ART OF BIOMEDICAL SCIENCE AND TECHNOLOGY IN TURKEY 110
A LOOK AT THE WORLD OF MEDICAL DEVICES AND MATERIALS 111
E. Alpkaya
PRODUCTION IN THE BIOMEDICAL FIELD 113
A. Aydn
BIOMEDICAL SCIENCE AND TECHNOLOGY IN TURKEY: PHARMACEUTICAL BIOTECHNOLOGY OVERVIEW 115
F.Oner
THE BIOMEDICAL FIELD : FROM THE VIEWPOINT OF BASIC SCIENCES 117
V. Hasirci
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