Current Research Activities:

Tissue engineering (bone, cartilage, nerve, cardiac tissue), adult and embryonic stem cell, biodegradable polymers, liposomes, drug delivery, hard tissue repair, surface modification.

Selected Publications:

• B.Başmanav, G.T.Köse, and V.Hasirci, Sequential Growth Factor Delivery From Complexed Microspheres For Bone Tissue Engineering, Biomaterials Vol.29, 4195-4204, 2008
• D.Yücel, H.Kenar, G.T.Köse, and V.Hasirci, Mesenchymal stem cell behaviour on topographical cues, Tissue Engineering Part A, Vol.15, Iss.5, Page 878, 2008
• M.E.Yalvaç, M.Ramazanoğlu, O.F.Bayrak, F.Şahin and G.T.Köse, Multipotent stem cells derived from human dental follicle show osteogenic and neurogenic differentiation, FEBS Journal, Vol.275, Page 91, 2008
• M.E.Yalvaç, O.F.Bayrak, G.T.Köse and F.Şahin, Neuron-like cells derived from human cervical cancer HeLa cells, International Journal of Immunogenetics, Vol. 34 Issue 4 Page 287-299, 2007
• H.Kenar , G.T.Köse, and V.Hasirci, “In vitro bone tissue engineering on patterned biodegradable polyester blends”, Biomaterials Vol.27, 885-895, 2006
• G. T. Köse, F.Korkusuz, A.Özkul, Y.Soysal, T. Özdemir, C.Yildiz, and V.Hasirci, “Tissue engineered cartilage on collagen and PHBV matrices”, Biomaterials, Vol.26, 5187 5197, 2005
• S.Ber, G.T.Köse, and V.Hasirci, “Bone tissue engineering on patterned collagen films: An in vitro Study”, Biomaterials, Vol. 26, Iss. 14, 1977-1986 , 2005
• G.T.Köse, F.Korkusuz, P.Korkusuz, and V. Hasırcı, “In vivo bone tissue generation on biodegradable polymeric scaffold”, Tissue Engineering, Vol.10, 7/8, 2004
• G.T.Köse, F.Korkusuz, P.Korkusuz, N.Purali, and V. Hasırcı, “In vitro bone tissue generation on biodegradable polymeric scaffold”, Biomaterials, Vol.24, pg. 4999-5007, 2003
• G.T.Köse, H. Kenar, N. Hasırcı and V. Hasırcı, “Macroporous Poly(3-hydroxybutyric acid-co-3 hydroxyvaleric acid) Matrices for Bone Tissue Engineering”, Biomaterials, Vol. 24, 1949-1958 , 2003
• G.T. Köse, F. Korkusuz, S.Ber, and V. Hasırcı, “Poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) Based Tissue Engineering Matrices”, Journal of Materials Science: Materials in Medicine, Vol.14, pg. 121-126 , 2003
• Tezcaner, G.T. Köse and V. Hasırcı, “Fundamentals of Tissue Engineering: Tissues and Applications”, Technology and Health care(Biomed 8 special issue), Vol.10 Iss. (3,4), pg. 203-216, 2002
• G.T. Köse, A. Tezcaner and V. Hasırcı, “Fundamentals of Tissue Engineering: Carrier Materials and an Application”, Technology and Health care(Biomed 8 special issue), Vol.10 Iss. (3,4), pg. 187-201 , 2002
• G.T. Köse, M.Y. Arıca and V. Hasırcı, “Low-Molecular-Weight Heparin-Conjugated Liposomes with Improved Stability and Hemocompatibility”, Drug Delivery, 5, 257-264 , 1997