Title:

Professor

Education:

Ph.D. Middle East Technical University , 1982
M.Sc. METU, 1973
B.Sc. METU, 1971

Contact:

Telephone: +90 312 2103193
e-mail: nhasirci@metu.edu.tr

• Biomaterials and biocompatibility: Synthesis of polymers as biomaterials, characterization, surface modification and analysis, testing of biocompatibility

• Wound Dressing Materials: Synthesis of polymeric films, membranes and sponges for artificial skin applications and use of Growth Factors for cell proliferation and medical applications

• Biodegradable Scaffolds: Use of polymeric matrices for cell adhesion and examine the parameters affecting cell proliferation

• Responsive Hydrogels: Prepration and characterization of polymeric hydrogels responsive to pH and temperature and their use in controlled drug delivery

• Enzyme Immobilization: Immobilization of enzymes on to polymeric supports for biosensor of biotechnological applications and testing of activities

• Controlled Release: Use of Polymeric matrices in controlled release of bioactive chemicals (drugs, pesticides, herbicides etc.)

• Bone Cement Compositions: New formulations of bone-cements with high mechanical properties

Selected Publications:

• Eda Ayse Aksoy, Antonella Motta, Mariangela Fedel, Claudio Migliaresi, Vasif Hasirci, Nesrin Hasirci, Plasma Protein Adsorption and Platelet Adhesion on Heparin-Immobilized Polyurethane Films, J. Bioactive and Compatible Polymers, 23, 505-519, 2008.

• K. Kamışoğlu, E. A. Aksoy, B. Akata, N. Hasirci  and  N. Baç, Preparation and
  Characterization of Antibacterial Zeolite - Polyurethane Composites, J. Applied Polymer Science, 110, 2854-2861, 2008.

• Melike Oruç, M. Gürhan Ulusoy, Yüksel Kankaya, Uğur Koçer, Kemal Şerbetçi, Nesrin Hasirci, Pulley reconstruction with different materials: Experimental study, Annals of Plastic Surgery, 61, 2, 215-220, 2008.

• Ayse E Aksoy, Vasif Hasirci, Nesrin Hasirci, Surface Modification of Polyurethanes with Covalent Immobilization of Heparin, Macromolecular Symposia, Macromol. Symp. 269, 145-153, 2008

• Canturk Ozcan, Pınar Zorlutuna, Vasıf Hasirci, Nesrin Hasirci, Influence of Oxygen Plasma Modification on Surface Free Energy of PMMA Films and Cell Attachment, Macromolecular Symposia, Macromol. Symp. 269, 128-137, 2008

• S. Uguralp, M. Akin, A B. Karabulut, B. Harma  A. Kiziltay, TR. Kıran, N. Hasirci,
  Reduction of peritoneal adhesions by sustained and local administration of epidermal growth factor,  Pediatr Surg Int., 24, 2, 191-197, 2008

• Pinar Yilgor, Rui A. Sousa, Rui L. Reis, Nesrin Hasirci, Vasif Hasirci, 3D Plotted PCL Scaffolds for Stem Cell Based Bone Tissue Engineering, Macromolecular Symposia, Macromol. Symp. 269, 92-99, 2008

• P.Zorlutuna, V.Hasirci, N.Hasirci, Nanopatterned Collagen Tubes for Vascular Tissue Engineering, J.Tissue Eng Regen Med, 2, 373-377, 2008

• Haydar Altinok, Serpil Aksoy, Hayrettin Tümtürk, Nesrin Hasirci, Covalent Immobilization of Invertase on Chemically Activated Poly(Styrene-2-hydroxyethyl methacrylate) Microbeads, Journal of Food Biochemistry, 32, 299-315, 2008

• Hayrettin Tümtürk, Gökhan Demirel, Haydar Altinok, Serpil Aksoy, Nesrin Hasirci, Immobilization of  Glucose Isomerase in Surface Modified Alginate Gel Beads, J. Food Biochemistry, 32, 234-246, 2008

• S. Uguralp, M. Akin, A B. Karabulut, B. Harma  A. Kiziltay, TR. Kıran, N. Hasirci,
  Reduction of peritoneal adhesions by sustained and local administration of epidermal growth factor,  Pediatr Surg Int., 24, 2, 191-197, 2008

• C. Ozcan; N. Hasirci, Evaluation of Surface Free Energy for PMMA Films, Journal of Applied Polymer Science, 108, 438-446, 2008

• Mine Fedakar Senyucel, Meltem Bingol-Kologlu, Rahsan Vargun, Canan Akbay, F.Nurşen Saraç, Nurten Renda, Nesrin Hasırcı, Gulnur Gollu, Hüseyin Dindar, The effects of local and sustained release of Fibroblast growth factor on wound healing in esophageal anastomoses, J. Pediatric Surgery, 43, 2, 290-295, 2008

• N.Hasirci, Micro and Nano systems in Biomedicine and Drug delivery, in ‘Nanomaterials and Nanosystems for Biomedical Applications’, Editor: M. Reza Mozafari, pp:1-26, Dordrecht, Netherlands, Springer, 2007

• Karakayali, F., Haberal, N., Tufan, H., Hasirci, N., BaSaran, O., Sevmis, S., Akdur, A., Kiziltay, A., Haberal, M., Evaluation of neointimal hyperplasia on tranilast-coated synthetic vascular grafts: An experimental study, Journal of Investigative Surgery 20 (3), pp. 167-173, 2007

• C. Ozcan, N.Hasirci, Plasma modification of PMMA films, surface free energy and cell-attachment studies, J. Biomater Sci. Polymer Edn., 18, 6, 759-773, 2007

• Nesrin Hasirci, E. A. Aksoy, Synthesis and Modification of  Polyurethanes for medical Applications, High Performance Polymers, 19, 621-637, 2007

• Kemal Serbetci, Hakan Kulacoglu, Ali Onder Devay, Nesrin Hasirci, Effects of
  Resterilization on Mechanical Properties of Polypropylene Meshes, The American Journal of Surgery, AJS 19, 3,  376-381, 2007

• E.Ayse Aksoy, Burcu Akata, N. Bac, N.Hasirci, Preparation and characterization of zeolite Beta-polyurethane composite membranes, Journal of Applied Polymer Science, 104, 3378-3387, 2007

• H.Altinok, S. Aksoy, H. Tumturk, N. Hasirci, Covalent Immobilization of invertase on chemically activated poly(2-hydroxyl methacrylate) microbeads, Russian Chemical Bullettin, International Edition, 55,10, 1860-1864, October 2006

• N.Hasirci, S.Aksoy, H.Tumturk, Activation of poly(dimer acid-co-alkyl polyamine) particles for covalent immobilization of a-amylase, Reactive and Functional Polymers, 66, 1546-1551, 2006

• M.S.Yildirim, M.Kesimer, N.Hasirci, N.Kilic, U.Hasanreisoglu, Adsorption of human salivary mucin onto glow-discharge plasma treated acrylic resin surfaces, J.Oral Rehabilitation, 33; 775-783, 2006

• Yeliz Tunc, Nesrin Hasirci, Akgul Yesilada, Kezban Ulubayram, Comonomer Effects on Binding Performances and Morphology of Acrylate-Based Imprinted Polymers, Polymer 47, 6931-6940, 2006

• G.Demirel, G.Ozcetin, F.Sahin, H.Tumturk, S.Aksoy, N.Hasirci, Semi-Interpenetrating polymer networks (IPNs) for entrapment of Glucose Isomerase, Reactive and Functional Polymers, 66, 389-394, 2006

• Burcu Basgorenay, Kezban Ulubayram, Kemal Serbetci, Erdal Onurhan, Nesrin Hasirci, Preparation modification and characterization of acrylic cements, Journal of Applied Polymer Science, 99, 3631-3637, 2006

• H. Oylum, E. Yilmaz, M. Bengisu, N. Hasirci, “Preparation and Characterization of Chitin Gels-A Comparative Study” Adv. in Chitin Sci. VIII (Eds. H. Struszyk, A. Domard, M.G. Peter, H. Pospieszny)    426-429 (2005) ESUS, Poznan, Poland.

• Kezban Ulubayram, Aysel Kiziltay, Elvan Yilmaz, Nesrin Hasirci, Desferrioxamine release from gelatin based sytems, Biotechnology and Applied Biochemistry, 42, 3, 237-245, 2005

• V.Hasirci, N.Hasirci,.Control of Polymeric Biomaterial Surfaces, Chapter 2 in Surfaces and Interfaces for Biomaterials, Ed.P.Vadgama,-CRC Press, Boca Raton, Woodhead Pub.Limited., Cambridge, England, ISBN: 0-8493-3446-6, 29-59, 2005

• M.S.Yildirim, U.Hasanreisoglu, N.Hasirci, N.Sultan, Adherence of Candida albicans to glow-discharge modified acylic denture base polymers, J.Oral Rehabilitation, 32, 518-525, 2005

• A.Muvaffak, I.Gurhan- Deliloglu, U.Gunduz, N.Hasirci, Preparation and characterization of a   biodegradable drug targeting system for anticancer delivery: Microsphere-antibody conjugate, Journal of Drug Targeting, 13(3), 151-159, 2005

• S.Uguralp, A.Bay Karabulut, B.Mizrak, F.Kaymaz, A.Kiziltay, N.Hasirci, The Effect of Sustained and Local Administration of Epidermal Growth Factor on Improving Bilateral Testicular Tissue After Torsion, Urological Research, 32, 323-331, 2004

• A. Muvaffak, I. Gürhan, N. Hasirci, Prolong cytotoxic effect colchicines released from biodegradable microspheres, Journal of Biomedical Materials Research PartB: Applied Biomaterials, 71B, 2, 295-304, 2004

• A. Muvaffak, I. Gürhan, N. Hasirci, Cytotoxicity of 5-fluorouracil entrapped in gelatin microspheres, Journal of Microencapsulation, 21, 3, 293-306, 2004

• N.Hasirci, V.Hasirci (Editors) Biomaterials; From Molecules to Engineered Tissues, Advances in experimental medicine and biology- Volume 553, pp 1-375, Kluwer/Plenum Publishers, New York, ISBN: 0-306-48583-4,  2004

• A.Burke, N.Hasirci, Polyurethanes in Biomedical Applications, in Biomaterials; From Molecules to Engineered Tissue, Eds: N.Hasirci and V.Hasirci, Kluwer/Plenum Publishers, New York, 2004, ISBN: 0-306-48583-4, p-83-101, 2004

• Fuat Güler, Meltem Bingöl-Kologlu, Aydin Yağmurlu, Cengiz Güven, Nesrin Hasirci, Özlem Küçük, Suat Aytaç and Hüseyin Dindar, The Effects of Local and Sustained Release of Fibroblast Growth Factor on Testicular Blood Flow And Morphology in Spermatic Artery and Vein-Ligated Rats, Journal of Pediatric Surgery, 39(5), 709-716, 2004

• A.Ebru Sakallioglu, Aydın Yagmurlu, Hüseyin Dindar, Nesrin Hasirci, Nurten Renda, M.Salih Deveci, Sustained Local Application of Low-Dose Epidermal Growth Factor on Steroid-Inhibited Colonic Would Healing, Journal of Pediatric Surgery, 39, 4, 591-595, 2004

• V.Hasirci, F.Korkusuz, N.Akkas, E.Bayramli, N.Hasirci, F.Severcan, M.Timucin,
  G.Alaeddinoglu, Production of Microbial Polyesters and Their Application in the
  Construction of Biodegradable, Controlled Antibiotic Release Systems, Tissue Engineering and Novel Delivery Systems, Ed: M.J.Yaszemski, D.J.Trantolo, K.Lewandrowski, V.Hasirci, D.E.Altobelli, D.L.Wise, ISBN: 0-8247-4786-0, Marcel-Dekker Inc. New York, 281-303, 2004

• K.Serbetci, F.Korkusuz, N.Hasirci, Thermal and Mechanical Properties of Hydroxyapatite Impregnated Acrylic Bone cements, Polymer Testing, 23, 145-155, 2004

• K.Serbetci, N.Hasirci, Recent Developments in Bone Cements, Biomaterials in Orthopedics, Ed: M.J.Yaszemski, D.J.Trantolo, K.Lewandrowski, V.Hasirci, D.E.Altobelli, D.L.Wise, Marcel-Dekker Inc. New York, 241-286, 2004

• A.Muvaffak, N.Hasirci, The Use of Antibodies in Diagnosis and Therapy of Cancer, Advances in Experimental Medicine and Biology (Adv Exp Med Biol), Volume 534, Tissue Engineering, in Stem Cells and Gene Therapies, Ed: M.Elcin, Kluwer Academic/ Plenium Publishers, New York, U.S.A., Chapter-23, 309-325, 2003, (Advances In Experimental Medicine And Biology, 534, 309-325, 2003

• G.Torun Kose, H.Kenar, N.Hasirci, V.Hasirci, Macroporous Poly
  (3-hydroxybutyrate-co-3-hydroxyvalerate) Matrices for Bone Tissue Engineering,
  Biomaterials, 24,11, 1949-1958, 2003

• V.Hasirci, A.Tezcaner, N.Hasirci, S.Suzer, Oxygen Plasma Modification of poly (3-hydroxy butyrate-co-3-hydroxy valerate) film surfaces for tissue engineering purposes J.Applied Polymer Science, 87, 1285-1289, 2003